Tannic acid repair of zearalenone-induced damage by regulating the death receptor and mitochondrial apoptosis signaling pathway in mice

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成果类型：

期刊论文

作者：

Wu, Jing;Li, Jiayan;Liu, Yanwei;Liao, Xinxin;Wu, Dongyi;...

通讯作者：

Wen, Lixin(sfwlx8015@sina.com)

作者机构：

[Wu, Jing; Liu, Yanwei; Chen, Yunqin; Li, Jiayan; Liao, Xinxin; Wu, Dongyi; Li, Rongfang; Yi, Jine; Yuan, Zhihang] Hunan Agr Univ, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

[Wu, Jing; Liu, Yanwei; Chen, Yunqin; Li, Jiayan; Liao, Xinxin; Wu, Dongyi; Li, Rongfang; Yi, Jine; Wen, Lixin; Yuan, Zhihang] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Wen, Lixin] Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Peoples R China.

[Liang, Zengenni] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China.

通讯机构：

[Lixin Wen] C

Colleges of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China<&wdkj&>Hunan Co-innovation Center of Animal Production Safety, Changsha, 410128, China

语种：

英文

关键词：

Apoptosis;Death receptor signaling pathway;Mitochondrial apoptosis signaling pathway;Oxidative stress;Zearalenone

期刊：

Environmental Pollution

ISSN：

0269-7491

年：

2021

卷：

287

页码：

117557

DOI：

10.1016/j.envpol.2021.117557

基金类别：

This work was supported through “Double First-Class” Disciplinary Construction Project of Hunan Agricultural University ( SYL2019049 ); the Education Department of Hunan Province (Grant No. 19B249 ); the National Key R&D Program of China (Grant No. 2016YDF0501200 ); China Postdoctoral Science Foundation (Grant No. 2017M620346 ); Graduate student scientific research in novation projects of Hunan province (Grant No. CX20190509 ) and the Special Funds for Construction of Innovative Provinces in Hunan Province ( 2020NK2032 ).

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Zearalenone (ZEA) is an estrogenic toxin produced by Fusarium strains, that is widely present in crops, and endangers the reproductive system of animals. Tannic acid (TA) is a natural polyphenolic substance that is widespread in the roots, stems, and leaves of plants, and has special pharmacological activity. This study was designed to investigate the therapeutic effect of TA on ZEA-induced ovarian damage in mice and to explore the molecular mechanism involved. Ninety healthy Kunming female mice were divided into six equal groups. All the group...

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Tannic acid repair of zearalenone-induced damage by regulating the death receptor and mitochondrial apoptosis signaling pathway in mice

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