期刊论文

Jine Yi

英文

ENVIRONMENTAL TOXICOLOGY

1520-4081

2025

40

4

608-623

10.1002/tox.24444

This paper was supported by the Natural Science Foundation of China (32273084), Innovation Foundation for Postgraduate of Hunan Province, China (CX20220670), Innovation Foundation for Postgraduate of Hunan Agricultural University, China (2022XC010), the Education Department of Hubei Province, China (B2020397), and the Major Science and Technology Project in Xiangyang City, China (011158671/2022-31663). You Huang and Chaoyang Ma contributed equally to this work.

本校为第一且通讯机构

As a conventional immunosuppressive drug, cyclophosphamide (CYP) exhibits strong hepatotoxicity in clinical applications. Betulinic acid (BA) is a natural triterpenoid that protects against liver damage. However, the underlying mechanism has not yet been elucidated. The purpose of this study was to evaluate the ameliorative effects of BA on CYP-induced hepatotoxicity and further clarify the underlying mechanism. BA pretreatment mitigated CYP-induced liver oxidative damage by alleviating histopathological lesions, reducing reactive oxygen species (ROS) accumulation, and restoring the mRNA expre...