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Dual-functional DNA nanoribbon-templated copper nanoclusters synergistically activate NRF2/HO-1 pathway for synergistic oxidative stress mitigation

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成果类型:
期刊论文
作者:
Li, Na;Long, Qinghong;Sui, Xin;Li, Yanlei;Li, Xinyuan;...
通讯作者:
Gao, Zhongfeng
作者机构:
[Li, Xinyuan; Sui, Xin; Liu, Fanglan; Li, Yingqi; Li, Na; Mai, Xi; Wang, Cheng; Long, Qinghong] School of Pharmacy, Jiangxi Medical College, Nanchang University, Jiangxi Province Key Laboratory of New Drug Evaluation and Transformation, Nanchang 330031, PR China
[Li, Yanlei] Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China
[Liu, Shigang] Hunan Provincial Key Laboratory of Food Science and Biotechnology, College of Food Science and Technology, Hunan Agricultural University, Changsha, PR China
[Gao, Zhongfeng] Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.. Electronic address: chm_gaozf@ujn.edu.cn
[Xia, Fan] Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, PR China
通讯机构:
[Gao, Zhongfeng] K
Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China.. Electronic address:
语种:
英文
关键词:
Antioxidant nanozyme;DNA nanotechnology;NRF2/HO-1 pathway;Oxidative stress;ROS
期刊:
Journal of Colloid and Interface Science
ISSN:
0021-9797
年:
2026
卷:
702
期:
Pt 1
页码:
138837
机构署名:
本校为其他机构
院系归属:
食品科学技术学院
摘要:
Employing antioxidant nanozymes to eliminate reactive oxygen species (ROS) is a promising strategy for alleviating oxidative stress. However, most current nanozymes struggle to balance catalytic efficacy with biosafety, limiting their clinical applicability. In this study, we introduce a novel platform: DNA nanoribbon-templated copper nanoclusters (DNR/Cu NCs), which harness dual antioxidative mechanisms (direct ROS scavenging and activation of nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway) to synergistically mitigate oxidative stress. Unlike conventional n...

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