Pretreatment with G-CSF Could Enhance the Antifibrotic Effect of BM-MSCs on Pulmonary Fibrosis.

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成果类型：

期刊论文

作者：

Zhao, Feiyan;Liu, Wei;Yue, Shaojie;Yang, Lei;Hua, Qingzhong;...

通讯作者：

Luo, Ziqiang;Tang, Siyuan

作者机构：

[Zhou, Yan; Luo, Ziqiang; Zhao, Feiyan; Cheng, Haipeng] Cent South Univ, Dept Physiol, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

[Yang, Lei; Zhao, Feiyan] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Liu, Wei; Hua, Qingzhong; Tang, Siyuan] Cent South Univ, Xiangya Nursing Sch, Changsha, Hunan, Peoples R China.

[Yue, Shaojie] Cent South Univ, Xiangya Hosp, Dept Pediat, Changsha, Hunan, Peoples R China.

通讯机构：

[Luo, Ziqiang; Tang, Siyuan] C

Cent South Univ, Dept Physiol, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

Cent South Univ, Xiangya Nursing Sch, Changsha, Hunan, Peoples R China.

语种：

英文

期刊：

Stem Cells International

ISSN：

1687-966X

年：

2019

卷：

2019

页码：

1726743

DOI：

10.1155/2019/1726743

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570065, 81500056, 81270121]; Hunan Province Natural Science Foundation, China [2016JJ3182]; Fundamental Research Funds for the Central Universities of Central South University [2016zzts115]; Open-End Fund for the Valuable and Precision Instrument of Central South University [CSUZC201740, CSUZC201735]; Innovation Fund for Institution of Higher Education of Hunan Province [11K076]; Fund for the Key Laboratory of Hunan Province, China [2017TP1004]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Granulocyte colony-stimulating factor (G-CSF) can promote the repair of a variety of damaged tissues, but the underlying mechanisms have not yet been fully elucidated. Bone marrow mesenchymal stem cells (BM-MSCs) play an important role in the repair of damaged tissue. The aim of this study was to explore whether pretreating BM-MSCs with G-CSF can promote their ability of homing to the lung after in vitro transplantation via upregulating the CXCR4 expression, potentially markedly increasing the antifibrotic effect of BM-MSCs. The BM-MSCs pretreated with G-CSF were transplanted into a mouse on d...

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Pretreatment with G-CSF Could Enhance the Antifibrotic Effect of BM-MSCs on Pulmonary Fibrosis.

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