Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets

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成果类型：

期刊论文

作者：

Li, Guanya;Xie, Chunyan;Wang, Qinhua;Wan, Dan*;Zhang, Yan;...

通讯作者：

Wan, Dan;Wu, Xin

作者机构：

[Li, Guanya; Wan, Dan; Wu, Xin; Wang, Qinhua; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.

[Li, Guanya; Wan, Dan; Wu, Xin; Wang, Qinhua; Yin, Yulong] Natl Engn Lab Pollut Control & Waste Utilizat Liv, Changsha 410125, Hunan, Peoples R China.

[Li, Guanya; Wan, Dan; Wu, Xin; Wang, Qinhua; Yin, Yulong] Hunan Prov Engn Res Ctr Healthy Livestock & Poult, Changsha 410125, Hunan, Peoples R China.

[Li, Guanya; Wang, Qinhua; Wu, Xin; Yin, Yulong; Xie, Chunyan] Hunan Agr Univ, Hunan Coinnovat Ctr Safety Anim Prod, Changsha 410128, Hunan, Peoples R China.

[Li, Guanya; Wang, Qinhua; Wu, Xin; Yin, Yulong; Xie, Chunyan] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Wan, D; Wu, X] C

[Wan, D; Wu, X] N

[Wan, D; Wu, X; Wu, Xin] H

[Wu, Xin] J

Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2019

卷：

期：

页码：

4081-4089

DOI：

10.1039/c9fo00360f

基金类别：

Funding for this study was provided by the National Key Research and Development Program of China (2016YFD0500504), the National Natural Science Foundation of China (31702127), the Science and Technology Service Network Initiative program of the Chinese Academy of Sciences (KFJ-STS-QYZX-031), the Young Elite Scientists Sponsorship Program by CAST (2018QNRC001), and CAS President’s International Fellowship for Visiting Scientists (2019VBA0015).

机构署名：

本校为通讯机构

院系归属：

生物科学技术学院

摘要：

Uridine monophosphate (UMP) is a major nucleotide analogue in mammalian milk and uridine (UR) is its gastro-intestinal metabolite in vivo. This study aims to investigate the functional effects of UMP and UR on the gut in vitro and in vivo. Twenty-one piglets were randomly allotted into three groups, the control group, UMP group and UR group, and orally administered UMP or UR for 10 days. Results showed that UMP and UR supplements improved the ADG of piglets, and decreased the diarrhea rate. UR increased the jejunum villus length/crypt depth rat...

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Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets

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