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miR-26a inhibits proliferation and promotes apoptosis in porcine immature Sertoli cells by targeting the PAK2 gene

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成果类型:
期刊论文
作者:
Ran, Maoliang;Weng, Bo;Cao, Rong;Li, Zhi;Peng, Fuzhi;...
通讯作者:
Chen, Bin
作者机构:
[Cao, Rong; Gao, Hu; Ran, Maoliang; Weng, Bo; Li, Zhi; Peng, Fuzhi; Luo, Hui; Chen, Bin] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
[Gao, Hu; Ran, Maoliang; Weng, Bo; Li, Zhi; Peng, Fuzhi; Luo, Hui; Chen, Bin] Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha, Hunan, Peoples R China.
通讯机构:
[Chen, Bin] H
Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
apoptosis;miR-26a;PAK2;proliferation;Sertoli cells
期刊:
Reproduction in Domestic Animals
ISSN:
0936-6768
年:
2018
卷:
53
期:
6
页码:
1375-1385
基金类别:
Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ3219] Funding Source: Medline; China Agriculture Research System [CARS-36] Funding Source: Medline; Excellent Doctoral Dissertation Cultivating Fund of Hunan Agricultural University [YB2015001] Funding Source: Medline
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
摘要:
ContentsAccumulating reports have demonstrated that microRNAs (miRNAs) participate in regulating the complex processes of animal testis development and spermatogenesis; yet, the mechanisms by which miRNAs regulate spermatogenesis are poorly understood. miR‐26a was identified as a miRNA that is differentially expressed among different pig testicular tissue developmental stages in our previous study. In this study, p21 activated kinase 2 (PAK2) gene was determined as one target gene of miR‐26a by luciferase reporter assay, and miR‐26a represse...

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