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The intestinal toxicity mechanisms of Triclosan and Triclocarban and their possible clinical nutritional intervention mechanisms

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成果类型:
期刊论文
作者:
Fang, Xinyu;Zhao, Jinfeng;Wu, Simin;Liao, Peng*;Guan, Guiping*
通讯作者:
Liao, Peng;Guan, Guiping
作者机构:
[Wu, Simin; Fang, Xinyu; Zhao, Jinfeng] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China
[Wu, Simin; Fang, Xinyu; Zhao, Jinfeng] Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan, 410125, China
[Liao, Peng] Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan, 410125, China
[Liao, Peng] Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha, Hunan, 410219, China. Electronic address: liaopeng@isa.ac.cn
[Guan, Guiping] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China. Electronic address: guanguiping@hunau.edu.cn
通讯机构:
[Guan, Guiping] C
[Liao, Peng] H
Hunan Provincial Key Laboratory of the TCM Agricultural Biogenomics, Changsha Medical University, Changsha, Hunan, 410219, China. Electronic address:
College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China. Electronic address:
语种:
英文
关键词:
Intestinal toxicity;Nutritional intervention;Triclocarban;Triclosan
期刊:
Environmental Pollution
ISSN:
0269-7491
年:
2025
卷:
376
页码:
126396
机构署名:
本校为第一且通讯机构
院系归属:
生物科学技术学院
摘要:
Triclosan (TCS) and triclocarban (TCC) are widely used as antimicrobial agents in personal care products. Their widespread use has become a potential environmental contaminant. This review reviews the mechanisms of intestinal toxicity of TCS and TCC and their potential nutritional intervention strategies. TCS and TCC can be metabolized to glucuronic acid conjugates in the host and subsequently uncoupled by microorganisms in the intestine to regenerate free forms of TCS and TCC. TCS and TCC are unique metabolic pathways that lead to accumulation...

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