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Integrative Analysis of Transcriptomics and Metabolomics Reveals the Effects of Western-Style Diets on Spleen Function

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成果类型:
期刊论文
作者:
Shengguo Tang;Dongfang Li;Yanna Ma;Zhiying Zhao;Liangyuan Peng;...
通讯作者:
Hongjiang Wei
作者机构:
Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650500, China
[Yanna Ma; Zhiying Zhao; Liangyuan Peng; Shuchao Liao] Institute of Yunnan Circular Agricultural Industry, Pu’er 665000, China
[Haiming Ma] College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Yunnan Agricultural University, Kunming 650500, China
Author to whom correspondence should be addressed.
通讯机构:
[Hongjiang Wei] F
Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650500, China<&wdkj&>Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Yunnan Agricultural University, Kunming 650500, China<&wdkj&>Author to whom correspondence should be addressed.
语种:
英文
关键词:
mice;spleen;immunity;transcriptomics;metabolomics
期刊:
Biology
ISSN:
2079-7737
年:
2025
卷:
14
期:
9
页码:
1136-
基金类别:
Conceptualization, H.W.; methodology, S.T. and D.L.; software, Y.M. and Z.Z.; validation, L.P. and S.L.; formal analysis, H.M.; data curation, S.T.; writing—original draft preparation, S.T.; writing—review and editing, H.W., visualization, S.T.; funding acquisition, H.W. All authors have read and agreed to the published version of the manuscript. This research was funded by the Major Science and Technology Project of Yunnan Province (202102AA100054).
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
The spleen is essential for immunity, mediating host defense against pathogens and regulating immunological homeostasis. Western-style diets commonly cause the aggregation of body fat and the emergence of obesity. This state might lead to damage to the spleen’s functions. However, the effects of Western-style diets on gene expression and metabolic regulation in the spleen have not yet been fully explored. In this study, C57BL/6 mice were fed either a high-fat diet (HFD) or standard chow (CHFD) for 10 weeks starting at 8 weeks old. Weekly weigh...

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