Multi-gram scale synthesis of a bleomycin (BLM) carbohydrate moiety: exploring the antitumor beneficial effect of BLM disaccharide attached to 10-hydroxycamptothecine (10-HCPT)

首页 > 成果 > 详情

认领

导出

Link by 万方学术期刊

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, MaoLin;Huang, Weiping;Jiang, Zhilin;Shi, Yonghui;Yuan, Sisi;...

通讯作者：

Zhou, Wen;Zhou, Li

作者机构：

[Fu, Kaishuo; Yuan, Sisi; Zhou, Wen; Huang, Weiping; Li, MaoLin] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China.

[Jiang, Zhilin] Puer Univ, Puer, Yunan, Peoples R China.

[Shi, Yonghui] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Pharm, Guangzhou 510120, Guangdong, Peoples R China.

[Chen, YongJun] Guangzhou Univ Chinese Med, South China Res Ctr Acupuncture & Moxibust, Med Coll Acu Moxi & Rehabil, Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China.

[Zhou, Li] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Zhou, Wen] G

[Zhou, Li] H

Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China.

Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

10 hydroxycamptothecin;bleomycin;dibutyltin;disaccharide;galactoside;aminolysis;antineoplastic activity;Article;carbohydrate analysis;controlled study;deacetylation;drug conjugation;drug selectivity;drug synthesis;glycosidation;HCT 116 cell line;HEK293T cell line;Hep-G2 cell line;human;human cell;IC50;in vitro study;priority journal

期刊：

NEW JOURNAL OF CHEMISTRY

ISSN：

1144-0546

年：

2019

卷：

期：

页码：

6010-6020

DOI：

10.1039/c8nj06191b

基金类别：

The work is supported in part by financial support from National Natural Science Foundation of China (No. 21772028, 31360456, 3106052), Start-up Foundation of Guangzhou University of Chinese Medicine for Young Scholar (A1-AFD018171Z) and General Scientific Research Project of Guangzhou (201804010325), and Science and Technology Plan of Puer City (No. 2014-38). We also thank professor Tian Xu very much for critical reading of our manuscript.

机构署名：

本校为通讯机构

院系归属：

理学院

摘要：

The “tumor-seeking” role of bleomycin (BLM) disaccharide has been demonstrated to serve as a promising tool for cancer diagnosis and a potential ligand for targeted therapy. However, these practical applications are often hampered by the lack of BLM disaccharide. Herein, an efficient multi-gram synthesis of peracetylated BLM disaccharide 20 is achieved by a TMSOTF-mediated glycosidation coupling manner in 43.6% overall yield in terms of benzyl galactoside. The critical innovation of the synthetic strategy is that inexpensive benzyl galactosid...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Multi-gram scale synthesis of a bleomycin (BLM) carbohydrate moiety: exploring the antitumor beneficial effect of BLM disaccharide attached to 10-hydroxycamptothecine (10-HCPT)

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问