Aim:
The aim of this study was to investigate the metabolism of Gelsemium elegans in human, pig,
goat and rat liver microsomes and to elucidate the metabolic pathways and cleavage patterns of the Gelsemium
alkaloids among different species.
Methods:
A human, goat, pig and rat liver microparticles were incubated in vitro. After incubating at 37°C for
1 hour and centrifuging, the processed samples were detected by HPLC/Qq-TOFMS was used to detect alcohol
extract of Gelsemium elegans and its metabolites.
Results:
Forty-six natural products w...
