[Li, Qing; Li, Xue; Fan, Ying; He, Jian; Lei, Hongyu] Hunan Agr Univ, Dept Prevent Vet Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
[Zhou, Lihua; Su, Jianming] Hunan Agr Univ, Dept Basic Vet Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Hongyu Lei; Jianming Su] D
Department of Basic Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China<&wdkj&>Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, Hunan, China
This work was supported by the Scientific Research Project of Hunan Provincial Education Department ( 19A229 ), and 2011 Collaborative Innovation Center of Hunan Province for Livestock Safety Production .
机构署名：
本校为第一机构
院系归属：
动物医学院
摘要：
Trimethyltin chloride (TMT) is a highly toxic substance produced by organotin heat stabilizers in the synthesis of polyvinyl chloride (PVC) products. TMT is widely used in industry and agriculture. The aim of this study was to investigate the effects of TMT-induced cytotoxicity in intestinal porcine epithelial cells (IPEC-J2). Our study showed that TMT induced a decline in cell viability of IPEC-J2, caused cell shrinkage and rounded cell morphology, reduced the number of proliferating cells and the expression of proliferating cell nuclear antig...
