More than 1 500 black guinea pigs stock in one farm of Hunan province was affected with an outbreak of disease in October,2014,leading to serious economic losses. According to statistic,the disease resulted in 100% for morbidity and 13. 33% for mortality. The clinical symptoms of anorexia,diarrhea and anal paste were observed,and diffuse hemorrhagic enteritis was also discovered in the death black guinea pigs. Meanwhile coccidian oocysts were microscopically observed in colon and its paraffin sections. So coccidiosis was initially determined. To reduce economic losses,the treatment of anti-coc...