期刊论文

中文

中南林业科技大学学报

1673-923X

2010

30

10

94-106

10.14067/j.cnki.1673-923x.2010.10.004

本校为第一机构

神经嵴是在神经管形成过程中分离出的一组多能干细胞群,随着细胞迁移,可分化成成体多种特定的细胞和组织。神经嵴的sox10突变体与一系列神经疾病相关,尽管sox10基因与神经胶质之间的关系现已得到一定的研究,但对其与感觉神经元之间作用的研究还留有很大空白。在本研究中,我们主要运用RNA探针原位杂交技术来检测一系列神经嵴系统发育标记在斑马鱼胚胎中的表达。本研究结果表明,sox10基因既能促进神经胶质发育,也能影响感觉神经元和自主神经的分化。在本研究中发现,sox10的功能缺陷,能导致产生冗余神经丘二级效应。此外,本研究还发现运用较广的斑马鱼m618突变体比近年新发现的baz1突变体有着更为严...

Neural crest is a transient group of multipotent cells that migrates extensively giving rise to a wide variety of derivatives, including pigment cells, neurons and glia. The understanding of sox10 function in neural crest development is essential because sox10 mutations underlie several neurocristopathies. Whereas the role of transcription factor sox10 in glial lineage has been well established, sox10 function in sensory neurons is more debatable. In this study, whole mount in situ hybridizations of developing wild-type and sox10 mutant zebrafish embryos were used to examine all kinds of marke...