Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis

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成果类型：

期刊论文

作者：

Zhao, Yucheng;He, Yuedong;Han, Liangliang;Zhang, Libo;Xia, Yuanzheng;...

通讯作者：

Xiao, YB;Kong, LY;Qiao, F

作者机构：

[Zhang, Libo; Zhao, Yucheng] China Pharmaceut Univ, Dept Resources Sci Tradit Chinese Med, Sch Tradit Chinese Pharm, Nanjing 210009, Peoples R China.

[Zhang, Libo; Xiao, Yibei; Zhao, Yucheng] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China.

[He, Yuedong] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

[Kong, Lingyi; Han, Liangliang; Wang, Xiaobing; Xia, Yuanzheng; Kong, LY; Yin, Fucheng] China Pharmaceut Univ, Dept Nat Med Chem, Jiangsu Key Lab Bioact Nat Prod Res, Nanjing 210009, Peoples R China.

[Kong, Lingyi; Han, Liangliang; Wang, Xiaobing; Xia, Yuanzheng; Kong, LY; Yin, Fucheng] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China.

通讯机构：

[Qiao, F ; Xiao, YB ; Kong, LY ] C

China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China.

China Pharmaceut Univ, Dept Nat Med Chem, Jiangsu Key Lab Bioact Nat Prod Res, Nanjing 210009, Peoples R China.

China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China.

Chinese Acad Trop Agr Sci, Key Lab Crop Gene Resources & Germplasm Enhancemen, Minist Agr, Trop Crops Genet Resources Inst, Haikou 517317, Peoples R China.

语种：

英文

关键词：

Tetrahydropyrans;Tetrahydrofurans;Baldwin rules;Coumarins;CYP450 cyclase

期刊：

药学学报(英文)

ISSN：

2211-3835

年：

2024

卷：

期：

页码：

869-880

DOI：

10.1016/j.apsb.2023.10.016

基金类别：

National Key Research and Development Program of China [2018YFA0902000]; Key project at central government level: the ability establishment of sustainable use for valuable Chinese medicine resources (China) [2060302]; Open foundation of Shaanxi University of Chinese Medicine state key laboratory of R&D of Characteristic Qin Medicine Resources (China) [SUCM-QM202202]; Fund of Traditional Chinese Medicine Institute of Anhui Dabie Mountain (China) [TCMADM-2023-18]; National Natural Science Foundation of China [32070364]; Hainan Provincial Natural Science Foundation of China [2019RC309]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

Pyran- and furanocoumarins are key representatives of tetrahydropyrans and tetrahydrofurans, respectively, exhibiting diverse physiological and medical bioactivities. However, the biosynthetic mechanisms for their core structures remain poorly understood. Here we combined multiomics analyses of biosynthetic enzymes in Peucedanum praeruptorum and in vitro functional verification and identified two types of key enzymes critical for pyran and furan ring biosynthesis in plants. These included three distinct P. praeruptorum prenyltransferases (PpPT1-3) responsible for the prenylation of the simple ...

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Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis

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