期刊论文

Gong, Hang;Cai, Changqun

英文

Microchimica Acta

0026-3672

2019

186

1

1-8

10.1007/s00604-018-3119-5

This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Department (No. 16A204), Hunan 2011 Collaborative Innovation Center of Chemical Engineering & Technology with Environmental Benignity, Effective Resource Utilization, the project of innovation team of the ministry of education (IRT_17R90) and “1515”academic leader team program of Hunan Agricultural University. Acknowledgments This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Department (No. 16A204), Hunan 2011 Collaborative Innovation Center of Chemical Engineering & Technology with Environmental Benignity, Effective Resource Utilization, the project of innovation team of the ministry of education (IRT_17R90) and B1515^academic leader team program of Hunan Agricultural University.

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A DNA-templated copper nanoparticle (CuNP) probe has been developed for the determination of the human immunodeficiency virus oligonucleotide (HIV-DNA). The function of the probe relies on affinity binding-induced DNA hybridization associated with the use of double G-quadruplexes. Double-stranded DNA(dsDNA) with poly(AT-TA) bases was used as a template for synthesis of dsDNA-CuNPs. These have weak fluorescence. In the next step, two G-rich sequences that are linked to both sides of the ds-DNA are locked by HIV complementary DNA (cDNA). If HIV-D...