期刊论文

Xiao, Tiaoyi;Lv, Z

英文

International Journal of Biological Macromolecules

0141-8130

2024

255

128192

10.1016/j.ijbiomac.2023.128192

Author statement Yadong Deng: Conceptualization, Formal analysis, Investigation, Data curation, Writing–review & editing. Chunhua Ding: Methodology, Visualization. Hong Yang: Methodology, Validation. Mengyuan Zhang: Formal analysis. Yu Xiao: Software, Visualization, Methodology. Hongquan Wang: Methodology. Junhua Li: Methodology, Validation. Tiaoyi Xiao: acquisition, Project administration, Supervision. Zhao Lv: acquisition, Conceptualization, Supervision, Validation, Writing–review & editing.

本校为第一且通讯机构

IL-1 beta is an important proinflammatory cytokine with multifaceted modulatory roles in immune responses. In fish, recombinant IL-1 beta has been employed in the control of bacterial diseases, while the antiviral mechanisms of IL-1 beta remain largely unknown, and the efficacy of recombinant IL-1 beta as an immunomodulator to prevent viral diseases is still not determined. This study evaluated the immunomodulatory effects of recombinant grass carp IL-1 beta against grass carp reovirus (GCRV) in vitro and in vivo. Firstly, the mature form (Ser(111)-Lys(270)) of grass carp IL-1 beta was identif...