期刊论文

中文

中兽医医药杂志

1000-6354

2019

38

2

5-8

10.13823/j.cnki.jtcvm.2019.02.001

湖南省***基金项目:基于代谢的中兽药作用物质基础与药理作用机制研究（2017JJ1017）；

本校为第一机构

研究钩吻素甲在猪体外肝S9的代谢.采用高效液相色谱串联四极杆飞行时间质谱(HPLC/QqTOFMS)对孵育后的代谢物进行结构鉴定.结果 表明,钩吻素甲在猪肝S9中仅检出2种代谢产物,根据原形及其代谢物的精确分子质量差和产物离子,鉴定了这2种代谢物结构,进而表明钩吻素甲的主要代谢途径是氧化和去甲基.

In this study, the metabolism of gelsemine in pig liver S9 was examined by rapid and accurate high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry(HPLC/QqTOFMS). The results showed that gelsemine only metabolized two metabolitesin pig liver S9. The structures of the two metabolites were identified according to their exact mass measurements and corresponding product ions. The major metabolic pathways of gelsem...