期刊论文

中文

中兽医医药杂志

1000-6354

2021

40

06

75-78

10.13823/j.cnki.jtcvm.2021.06.017

湖南农业大学大学生创新项目（XCX19051）； 国家重点研发计划专项:畜禽用新剂型研制开发（2017YFD0501403）；

本校为第一机构

探讨叶下珠醇提物对肠炎沙门菌毒素所致小鼠脾脏和回肠氧化损伤的影响.给小鼠连续灌服叶下珠醇提物(40 mg/mL、20 mg/mL、10 mg/mL,分别记为PH组、PM组、PL组),7d后,腹腔注射肠炎沙门菌毒素,观察其对小鼠体质量和脾脏指数的影响,测定小鼠脾脏和肠MDA、T-AOC、SOD、GSH-Px水平.结果 显示肠炎沙门菌毒素可致脾脏明显肿胀,与对照组相比,肠炎沙门菌毒素可致脾脏指数极显著升高(P＜0.01),脾脏和回肠中MDA含量和T-AOC活性极显著升高(P＜0.01),SOD活性和GSH-Px活性极显著降低(P＜0.01),出现明显的脾脏和肠氧化应激反应.与毒素组相比,PH组和PL组脾脏指数极显著降低(P＜0.01),PM组脾脏指数显著降低(P＜0....

To investigate the effect of alcohol extract of Phyllanthus urinaria on oxidative damage of spleen and intestine in mice induced by Salmonella enteritis toxin.Mice were continuously perfused with alcohol extract of Phyllanthus urinaria(40 mg·mL-1,20 mg·mL-1 and 10 mg·mL-1,respectively recorded as PH group,PM group and PL group).After 7 days,Salmonella enteritidis toxin was injected intraperitoneally to observe its effects on body mass and spleen index,and MDA,T-AOC,SOD and GSH-Px in spleen and intestine were measured.The results showed that ...