期刊论文

Effects of ethanol extract of Phyllanthus urinaria on inflammation induced by Salmonella enteritidis toxin in mice

中文

中兽医医药杂志

1000-6354

2022

41

01

54-58

10.13823/j.cnki.jtcvm.2022.01.012

湖南农业大学大学生创新项目（XCX19051）； 国家重点研发计划专项：畜禽用新剂型研制开发（2017YFD0501403）；

本校为第一机构

研究叶下珠醇提物对攻毒肠炎沙门菌(Salmonella enteritidis)毒素小鼠血清、肝、脾和空肠炎症因子水平的影响.将50只昆明小鼠随机分为空白对照组(CK)、肠炎沙门菌毒素组、叶下珠醇提物高剂量组、中剂量组和低剂量组(40 mg/mL、20 mg/mL和10 mg/mL).各组灌胃叶下珠醇提物7 d,除对照组外,其余各组均腹腔注射肠炎沙门菌毒素,24 h后采血,扑杀各组小鼠,快速分离肝、脾和空肠组织,ELISA测定小鼠血清中IL-6、TNF-α和IL-10水平.结果表明,与对照组相比,肠炎沙门菌毒素组小鼠腹泻等临床症状明显,剖检可见肝、脾、肠出血肿胀等病变,叶下珠醇提物各剂量组小鼠临床症状和脏器损伤均明显轻于肠炎沙门菌毒素组...

To study the effects of ethanol extract of Phyllanthus urinaria on the levels of inflammatory factors in serum,liver,spleen and jejunum of mice challenged with Salmonella enteritidis toxin,50 Kunming mice were randomly divided into blank control group(CK),toxin group,Phyllanthus urinaria alcohol extract high(PH),medium(PM)and low(PL)dose groups(40 mg·mL;,20 mg·mL;and 10 mg·mL;). After 7 days of intragastric administration of ethanol extract of Phyllanthus urinaria,except for the control group,all mice were intraperitoneally injected with tox...