Activation of glucocorticoid receptors is associated with the suppression of antioxidant responses in the liver of goats fed a high-concentrate diet

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成果类型：

期刊论文

作者：

Wang, Yan;Salem, Abdelfattah Z. M.;Tan, Zhiliang;Kang, Jinhe*;Wang, Zheng*

通讯作者：

Kang, Jinhe;Wang, Zheng

作者机构：

[Wang, Zheng; Kang, Jinhe; Wang, Yan] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Hunan, Peoples R China.

[Tan, Zhiliang; Wang, Yan; Kang, Jinhe] Chinese Acad Sci, Natl Engn Lab Pollut Control & Waste Utilizat Liv, CAS Key Lab Agroecol Proc Subtrop Reg,Inst Subtro, South Cent Expt Stn Anim Nutr & Feed Sci,Minist A, Changsha, Hunan, Peoples R China.

[Wang, Yan] Hunan Univ Humanities Sci & Technol, Coll Agr & Biotechnol, Loudi, Hunan, Peoples R China.

[Tan, Zhiliang; Wang, Yan; Kang, Jinhe] CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha, Hunan, Peoples R China.

[Salem, Abdelfattah Z. M.] Univ Autonoma Estado Mexico, Fac Med Vet & Zootecnia, Mexico City, DF, Mexico.

通讯机构：

[Kang, JH; Wang, Z] H

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Antioxidant response;high-concentrate diet;nuclear factor E2-related factor 2;glucocorticoid receptor

期刊：

ITALIAN JOURNAL OF ANIMAL SCIENCE

ISSN：

1594-4077

年：

2021

卷：

期：

页码：

195-204

DOI：

10.1080/1828051X.2021.1873706

基金类别：

This work was jointly supported by the National Natural Science Foundation of China [31760678]; the Youth Innovation Team Project of ISA, the Chinese Academy of Sciences [Grant numbers 2017QNCXTD_ZCS]; Open Fund of Key Laboratory of Agro-ecological Processes in Subtropical Region, Chinese Academy of Sciences [Grant numbers ISA2017304]; CAS Science and Technology Service Network Initiative [Grant numbers KFJ-STS-ZDTP-075]; Hunan Provincial Natural Science Foundation [2019JJ40134, 2020JJ5634], the Scientific Research Fund of Hunan Provincial Education Department [18A098], and Hunan Provincial Graduate Research and Innovation Project [CX2018B404]. And there are two projects, namely, the Scientific Research Fund of Hunan Provincial Education Department [18A098] and Hunan Provincial Graduate Research and Innovation Project [CX2018B404].

机构署名：

本校为第一且通讯机构

院系归属：

生物科学技术学院

摘要：

This study investigated changes in oxidative stress and the relevant mechanisms in the liver of goats fed a high-concentrate (HC) diet for 5 weeks. Twelve goats were randomly assigned to a low-concentrate (concentrate-to-forage = 55:45, LC, n = 6) or HC diet (concentrate-to-forage = 90:10, n = 6), with dry matter as the base. Enzyme activity assays, real-time polymerase chain reaction and western blotting were used to evaluate antioxidant parameters and gene expression in the liver. Superoxide dismutase (SOD), glutathione peroxidase (GPx),...

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Activation of glucocorticoid receptors is associated with the suppression of antioxidant responses in the liver of goats fed a high-concentrate diet

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