Comparative toxicokinetic profiles of multiple-components of Gelsemium elegans in pigs and rats after a single oral administration

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成果类型：

期刊论文

作者：

Cao, Jun-Jie;Yang, Kun;Yu, Hui;Long, Xue-Ming;Li, Yu-Juan;...

通讯作者：

Liu, Zhao-Ying

作者机构：

[Yu, Hui; Li, Yu-Juan; Sun, Zhi-Liang; Yang, Kun; Liu, Zhao-Ying; Cao, Jun-Jie] Hunan Agr Univ, Coll Vet Med, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

[Yu, Hui; Li, Yu-Juan; Sun, Zhi-Liang; Liu, Zhao-Ying; Cao, Jun-Jie] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

[Long, Xue-Ming] Hunan Prov Inst Vet Drugs & Feed Control, 61 Xiaoxiangzhong Rd, Changsha 410006, Hunan, Peoples R China.

通讯机构：

[Liu, Zhao-Ying] H

Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, 1 Nongda Rd, District Furong, Changsha City, 410128, Hunan, China. Electronic address:

语种：

英文

关键词：

Gelsemium;Toxicity;Rat;Gelsedine;Alkaloids;Gelsenicine

期刊：

Toxicon

ISSN：

0041-0101

年：

2020

卷：

181

页码：

28-35

DOI：

10.1016/j.toxicon.2020.04.093

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31972737]; Scientific Research Foundation of Hunan Provincial Education DepartmentHunan Provincial Education Department [18A088]; Double first-class construction project of Hunan Agricultural University [kxk201801008]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Gelsemium elegans Benth (G. elegans) is highly toxic to humans and rats, but has insecticides and growth promoting effects on pigs and goats. G. elegans is widely used in livestock, but its in vivo dynamics are entirely unknown. Hence, we investigated the toxicokinetic profiles of G. elegans alkaloids after a single oral dose of G. elegans to pigs (1.0 g/kg) and rats (0.1 g/kg). The results indicated that rats were more susceptible to the toxicity of G. elegans than pigs. The toxicokinetic parameters of 22 and 6 components were obtained in pigs...

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Comparative toxicokinetic profiles of multiple-components of Gelsemium elegans in pigs and rats after a single oral administration

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