Ca2+ as an essential signaling molecule controlling Snf1-mediated Atg1 activation - 成果

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Ca²⁺ as an essential signaling molecule controlling Snf1-mediated Atg1 activation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Yanyang;Yi, Cong

通讯作者：

Yi, C

作者机构：

[Wu, Yanyang] Hunan Agr Univ, Coll Food Sci & Technol, Key Lab Food Sci & Biotechnol Hunan Prov, Changsha, Peoples R China.

[Yi, Cong] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Biochem, Hangzhou, Peoples R China.

[Yi, Cong] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Peoples R China.

[Yi, C] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China.

[Yi, C] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310058, Peoples R China.

通讯机构：

[Yi, C ] Z

Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Biochem, Hangzhou 310058, Peoples R China.

Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310058, Peoples R China.

语种：

英文

关键词：

Atg11-Bmh1/2-Snf1 complex;Ca2+;Rck2;autophagy;glucose starvation

期刊：

Autophagy

ISSN：

1554-8627

年：

2024

页码：

1-2

DOI：

10.1080/15548627.2024.2389483

基金类别：

National Natural Science Foundation of China [32122028, 92254307, 32070739, 31601125, 32072334]

机构署名：

本校为第一机构

院系归属：

食品科学技术学院

摘要：

Macroautophagy/autophagy is essential for maintaining glucose homeostasis, but the mechanisms by which cells sense glucose starvation and initiate autophagy are not yet fully understood. Recently, we reported that the assembly of a Ca(2+)-triggered Snf1-Bmh1/Bmh2-Atg11 complex initiates autophagy in response to glucose starvation. Our research reveals that during glucose starvation, the efflux of vacuolar Ca(2+) increases cytoplasmic Ca(2+) levels, which activates the protein kinase Rck2. Rck2-mediated phosphorylation of Atg11 enhances its interaction with Bmh1 and Bmh2. This interaction recru...

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