Arsenic Exposure-Induced Acute Kidney Injury by Regulating SIRT1/PINK1/Mitophagy Axis in Mice and in HK-2 Cells

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成果类型：

期刊论文

作者：

Liu, Shuiping;Liu, Yunhuan;Li, Jinyan;Wang, Mengmeng;Chen, Xingxiang;...

通讯作者：

Huang, Kehe;Liu, DD

作者机构：

[Liu, Shuiping; Wen, Lixin] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Liu, Yunhuan; Li, Jinyan; Huang, Kehe; Liu, Shuiping; Chen, Xingxiang; Liu, Dandan; Wang, Mengmeng; Liu, DD; Gan, Fang] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China.

[Liu, Yunhuan; Li, Jinyan; Huang, Kehe; Liu, Shuiping; Chen, Xingxiang; Liu, Dandan; Wang, Mengmeng; Liu, DD; Gan, Fang] Nanjing Agr Univ, Inst Anim Nutr Hlth, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China.

[Liu, Yunhuan; Li, Jinyan; Huang, Kehe; Liu, Shuiping; Chen, Xingxiang; Liu, Dandan; Wang, Mengmeng; Liu, DD; Gan, Fang] Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Jiangsu, Peoples R China.

通讯机构：

[Huang, KH; Liu, DD ] N

Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China.

Nanjing Agr Univ, Inst Anim Nutr Hlth, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China.

Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Jiangsu, Peoples R China.

语种：

英文

关键词：

arsenic;acute kidney injury;SIRT1;mitophagy;PINK1

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2023

卷：

期：

页码：

15809-15820

DOI：

10.1021/acs.jafc.3c05341

基金类别：

Natural Science Foundation of Jiangsu Province [BK20221013]; National Natural Science Foundation of China [32072926, 31772811]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Groundwater resources are often contaminated by arsenic, which poses a serious threat to human and animal's health. Some studies have demonstrated that acute arsenic exposure could induce kidney injury because the kidney is a key target organ for toxicity, but the exact mechanism remains unclear. Hence, we investigated the effect of SIRT1-/PINK1-mediated mitophagy on NaAsO(2)-induced kidney injury in vivo and in vitro. In our study, NaAsO(2) exposure obviously induced renal tubule injury and mitochondrial dysfunction. Meanwhile, NaAsO(2) exposure could inhibit the mRNA/protein level of SIRT1 a...

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Arsenic Exposure-Induced Acute Kidney Injury by Regulating SIRT1/PINK1/Mitophagy Axis in Mice and in HK-2 Cells

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