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A high-throughput QCM chip configuration for the study of living cells and cell-drug interactions

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成果类型:
期刊论文
作者:
Shen, Haibo;Zhou, Tiean*;Hu, Jiajin
通讯作者:
Zhou, Tiean
作者机构:
[Shen, Haibo; Zhou, Tiean; Hu, Jiajin] Hunan Agr Univ, Cell Mech & Biosensing Inst, 405 Life Sci Bldg, Changsha 410128, Hunan, Peoples R China.
[Shen, Haibo; Zhou, Tiean; Hu, Jiajin] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Zhou, Tiean] H
Hunan Agr Univ, Cell Mech & Biosensing Inst, 405 Life Sci Bldg, Changsha 410128, Hunan, Peoples R China.
Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
Quartz crystal microbalance;High-throughput;Cell phenotype;Viscoelasticity;H9C2 cardiomyoblasts;Cell-drug interactions
期刊:
Analytical and Bioanalytical Chemistry
ISSN:
1618-2642
年:
2017
卷:
409
期:
27
页码:
6463-6473
基金类别:
Funding information This work was supported in part by grants from the Key Project of Hunan Provincial Science & Technology Department (2013TT1009) and the National Natural Science Foundation of China (21275048).
机构署名:
本校为第一且通讯机构
院系归属:
生物科学技术学院
摘要:
In this study, we present a novel design of interference-free, negligible installation-induced stress, suitable for the fabrication of high-throughput quartz crystal microbalance (HQCM) chips. This novel HQCM chip configuration was fabricated using eight independent yet same-batch quartz crystal resonators within a common glass substrate with eight through-holes of diameter slightly larger than that of the quartz resonator. Each quartz resonator's rim was adhered to the inner part of the through-hole via silicone glue to form the rigid (quartz)-soft (silicone)-rigid (glass) structure (RSRS) wh...

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