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MAVS integrates glucose metabolism and RIG-I-like receptor signaling

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成果类型:
期刊论文
作者:
He, Qiao-qiao;Huang, Yu;Nie, Longyu;Ren, Sheng;Xu, Gang;...
通讯作者:
Zhu, Ying;Liu, S
作者机构:
[Zhu, Ying; Liu, Shi; Xu, Ke; Zhou, Li; Huang, Yu; Zuo, Qi; Ren, Sheng; Cheng, Zhikui; Yan, Huan; Liu, S; He, Qiao-qiao; Deng, Feiyan; Zhu, Y; Nie, Longyu; Xu, Gang] Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, State Key Lab Virol,Frontier Sci Ctr Immunol & Met, Wuhan 430072, Peoples R China.
[Liu, Shi; Lu, Zhibing; Zhang, Lin; Liu, S; Cai, Huanhuan] Wuhan Univ, Inst Myocardial Injury & Repair, Wuhan 430072, Peoples R China.
[Lu, Zhibing; Zhang, Lin; Cai, Huanhuan] Wuhan Univ, Dept Cardiol, Zhongnan Hosp, Wuhan 430072, Peoples R China.
[Liu, Shi; Wang, Qiming; Liu, S] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
[Liu, Shi; Wang, Fubing; Liu, S] Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan 430072, Peoples R China.
通讯机构:
[Liu, S ; Zhu, Y] W
Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, State Key Lab Virol,Frontier Sci Ctr Immunol & Met, Wuhan 430072, Peoples R China.
Wuhan Univ, Inst Myocardial Injury & Repair, Wuhan 430072, Peoples R China.
Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
Chinese Acad Med Sci, Wuhan Res Ctr Infect Dis & Canc, Wuhan 430072, Peoples R China.
语种:
英文
期刊:
Nature Communications
ISSN:
2041-1723
年:
2023
卷:
14
期:
1
页码:
5343
基金类别:
This work was supported by the National Key Research and Development Program of China (2021YFC2701800, 2021YFC2701804), the National Natural Science Foundation of China (U22A20335), the Fundamental Research Funds for the Central Universities (2042022dx0003 [2021YFC2701804, 81872262]; National Key Research and Development Program of China [2042021kf023]; National Natural Science Foundation of China [2021CFA054]; Fundamental Research Funds for the Central Universities [2021RC5006]; Science Fund for Distinguished Young Scholars of Hubei Province; Huxiang high-level talents gather engineering innovation and entrepreneurship talents in Hunan province; Deutsche For schungsgemeinschaft; [2021YFC2701800]
机构署名:
本校为通讯机构
院系归属:
生物科学技术学院
摘要:
MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling in mitochondria, peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of MAVS in glucose metabolism and RLR signaling cross-regulation and how these signaling pathways are coordinated among these organelles have not been defined. This study reports that RLR action drives a switch from glycolysis to the pentose phosphate pathway (PPP) and the hexosamine biosynthesis pathway (HBP) through MAVS. We show that peroxisomal MAVS is responsible for glucose flux shift into PPP and type III interferon (...

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