期刊论文

英文

Molecules

1420-3049

2023

28

1

10.3390/molecules28010029

Natural Science Foundation of Hunan Province [2021JJ20044]; Changsha Natural Science Funds for Distinguished Young Scholar [kq2009020]; Science and Technology Innovation Program of Hunan Province [2022RC1159]; National Key Research and Development Programs of China [2022YFD1300503]; China Agriculture Research System of MOF and MARA [CARS-35]

本校为其他机构

Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to maintain their normal physiologic function. Iron deficiency impairs mitochondrial metabolism and respiratory activity, while mitochondrial iron overload promotes ROS production during mitochondrial electron transport, thus promoting potential disease development. This review provides an overview of iron homeostasis, mitochondrial iron metabolis...