Betulinic acid attenuates dexamethasone-induced oxidative damage through the JNK-P38 MAPK signaling pathway in mice

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成果类型：

期刊论文

作者：

Zhu, Lijuan;Yi, Xianglian;Zhao, Jing;Yuan, Zhihang;Wen, Lixin;...

通讯作者：

Wu, Jing;Yi, Jine

作者机构：

[Tan, Zhuliang; Wu, Jing; Yi, J; Yi, Xianglian; Zhao, Jing; Zhu, Lijuan; Wen, Lixin; Yi, Jine; Yuan, Zhihang] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Pozniak, Blazej; Obminska-Mrukowicz, Bozena] Wroclaw Univ Environm & Life Sci, Fac Vet Med, Dept Pharmacol & Toxicol, Norwida 31, PL-50375 Wroclaw, Poland.

[Zhu, Lijuan] Changsha Lvye Biotechnol Co Ltd, Changsha 410199, Hunan, Peoples R China.

[Tian, Yanan] Texas A&M Univ, Coll Vet Med, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA.

通讯机构：

[Wu, J; Yi, J] H

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Betulinic acid;Dexamethasone;Oxidative damage;Apoptosis;JNK;P38

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2018

卷：

103

页码：

499-508

DOI：

10.1016/j.biopha.2018.04.073

基金类别：

We are grateful for the financial support from the Department of Science and Technology of Hunan Province, China (Grant No. 2015NK3008 ), Natural Science Foundation of Hunan Province, China (Grant No. 2015JJ2077 ), Department of Education of Hunan Province, China (Grants No. 17A098 and 17B125), Postdoctoral Science Foundation, China ( 2017M620346 ).

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Dexamethasone (Dex), a potent anti-inflammatory/immunosuppressive agent, has been shown to induce oxidative stress. Betulinic acid (BA) is a pentacyclic lupane triterpene with a potent antioxidant activity. The aim of this study was to investigate the ameliorative effect and underlying mechanisms of BA on Dex-induced oxidative damage. Mice were pretreated with BA orally (0, 0.25, 0.5, and 1.0 mg/kg) daily for 14 days, and then a single dose of Dex (25 mg/kg body weight) was administered intraperitoneally 8 h after the last administration of BA ...

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Betulinic acid attenuates dexamethasone-induced oxidative damage through the JNK-P38 MAPK signaling pathway in mice

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