期刊论文

Yi, Jin-E;Yuan, Zhihang

英文

Biomolecules

2218-273X

2019

9

12

10.3390/biom9120787

Funding: This study was supported by China Postdoctoral Science Foundation (Grant No. 2017M620346), Graduate student scientific research innovation projects of Hunan province (Grant No. CX20190509), Scientific Research Project of Hunan Provincial Education Department (Grant No. 17B125 and 17C0766) and Projects of “Double First-Class” initiative in Hunan Agricultural University (Grant No. kxk201801004), National Natural Science Foundation of China (grant number: 31802238, 31572563, and 31501484), the Natural Science Foundation of Hunan Province, China (grant number: 2019JJ50272), the Provincial Agricultural Science and Technology Innovation Fund (grant number: 2018QN27), Hunan innovation and entrepreneurship technology investment project (grant number: 2017GK5009).

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T-2 toxin is one of the most toxic type A trichothecene mycotoxins in nature, and it exhibits reproductive toxicity. Betulinic acid (BA) is a natural pentacyclic triterpene compound found in species of Betula, and it has been reported to have antioxidant activity. The aim of the present study was to investigate the protective effect of BA on T-2-toxin-induced testicular injury in mice and explore its molecular mechanism. Sixty adult male mice were randomly divided into groups. The mice were pretreated orally with BA (0.25, 0.5, and 1.0 mg/kg) d...