Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway

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成果类型：

期刊论文

作者：

Zhu, Lijuan;Yi, Xianglian;Ma, Chaoyang;Luo, Chenxi;Kong, Li;...

通讯作者：

Wu, Jing;Yi, Jine

作者机构：

[Luo, Chenxi; Li, Rongfang; Wen, Lixin; Yi, Jine; Ma, Chaoyang; Kong, Li; Yuan, Zhihang; Wu, Jing; Lin, Xing; Gao, Xinyu; Yi, Xianglian; Zhu, Lijuan; Yi, JN] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Li, Rongfang; Wen, Lixin; Yi, Jine; Yuan, Zhihang; Wu, Jing; Yi, JN] Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

[Li, Rongfang; Wen, Lixin; Yi, Jine] Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Peoples R China.

通讯机构：

[Wu, J; Yi, JN; Yi, Jine] H

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Peoples R China.

语种：

英文

关键词：

T-2 toxin;thymus;betulinic acid;MAPK;Nrf2;oxidative stress

期刊：

TOXINS

ISSN：

2072-6651

年：

2020

卷：

期：

页码：

540

DOI：

10.3390/toxins12090540

基金类别：

Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2020JJ4368]; "Double First-Class" Disciplinary Construction Project of Hunan Agricultural University [SYL2019049]; Innovation Research and Development Project of Hunan Development and Reform Commission [37]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

T-2 toxin, the most toxic of the trichothecenes, is widely found in grains and feeds, and its intake poses serious risks to the health of humans and animals. An important cytotoxicity mechanism of T-2 toxin is the production of excess free radicals, which in turn leads to oxidative stress. Betulinic acid (BA) has many biological activities, including antioxidant activity, which is a plant-derived pentacyclic triterpenoid. The protective effects and mechanisms of BA in blocking oxidative stress caused by acute exposure to T-2 toxin in the thymus of mice was studied. BA pretreatment reduced ROS ...

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Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway

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