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Betulinic acid attenuates T-2 toxin-induced lung injury by activating Nrf2 signaling pathway and inhibiting MAPK/NF-κB signaling pathway

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成果类型:
期刊论文
作者:
Huang, Chunlin;Ou, Zhaoping;Kong, Li;Huang, You;Yang, Wenjiang;...
通讯作者:
Yu Zhou<&wdkj&>Jine Yi
作者机构:
[Huang, Chunlin] Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. Electronic address: huangchunlin@stu.hunau.edu.cn
[Ou, Zhaoping] Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. Electronic address: ouzhaoping@stu.hunau.edu.cn
[Kong, Li] Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. Electronic address: kongli@stu.hunau.edu.cn
[Huang, You] Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. Electronic address: huangyou@stu.hunau.edu.cn
[Yang, Wenjiang] Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. Electronic address: yangwenjiang@stu.hunau.edu.cn
通讯机构:
[Yu Zhou] M
[Jine Yi] H
Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China<&wdkj&>Medical College, Hunan Polytechnic of Environment and Biology, Hengyang, China
语种:
英文
关键词:
Betulinic acid;Lung impairment;MAPK/NF-κB signaling pathways;Nrf2 signaling pathway;T-2 toxin
期刊:
Toxicon
ISSN:
0041-0101
年:
2024
卷:
241
页码:
107652
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
T-2 toxin, a type-A trichothecene mycotoxin, exists ubiquitously in mildewed foods and feeds. Betulinic acid (BA), a pentacyclic triterpenoid derived from plants, has the effect of relieving inflammation and oxidative stress. The purpose of this study was to investigate whether BA mitigates lung impairment caused by T-2 toxin and elucidate the underlying mechanism. The results indicated that T-2 toxin triggered the inflammatory cell infiltration, morphological alterations and cell apoptosis in the lungs. It is gratifying that BA ameliorated T-2...

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