期刊论文

Zhang, Jian;Fan, Xiujun;Nayak, Nihar R.

英文

THERANOSTICS

1838-7640

2018

8

10

2765-2781

10.7150/thno.22904

National Key Research and Development Program of China [2016YFC1000402]; National Natural Sciences FoundationNational Natural Science Foundation of China (NSFC) [81571445, 81771617]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030313178]; Shenzhen Basic Research Fund [JCYJ20150521094519488, JCYJ20170413165233512]; Public Welfare Project of Guangdong Province [2017A020 211033]; US National Institute of Child Health and Human DevelopmentUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [HD088549-01]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31571013, 81501580]; Key International S&T Cooperation Project [2015DFH50230]; NATIONAL EYE INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [R01EY017182] Funding Source: NIH RePORTER

本校为其他机构

Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum-infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs. Methods: ...