期刊论文

Liu, Shi

英文

Hepatology

0270-9139

2020

72

2

518-534

10.1002/hep.31045

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872262, 31500149, 31570870, 81301428, 81802627]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2042017kf0221, 2042015kf0188]; Science and Technology Innovation Fostering Foundation of Zhongnan Hospital of Wuhan University [cxpy20160025]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [TRR60, RTG1949]; the Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [RTG1949, TRR60] Funding Source: Medline; the Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2042017kf0221, 2042015kf0188] Funding Source: Medline; the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31500149, 81872262, 81802627, 81301428, 31570870] Funding Source: Medline; Science and Technology Innovation Fostering Foundation of Zhongnan Hospital of Wuhan University [cxpy20160025] Funding Source: Medline

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Background and Aims Major vault protein (MVP) is up-regulated during infections with hepatitis B virus (HBV) and hepatitis C virus (HCV). Here, we found that MVP deficiency inhibited hepatocellular carcinoma (HCC) development induced by diethylnitrosamine, hepatitis B X protein, and HCV core. Approach and Results Forced MVP expression was sufficient to induce HCC in mice. Mechanistic studies demonstrate that the ubiquitin ligase human double minute 2 (HDM2) forms mutual exclusive complexes either with interferon regulatory factor 2 (IRF2) or with p53. In the presence of MVP, HDM2 is liberated ...