Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

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成果类型：

期刊论文

作者：

Xiong, Li-Gui;Chen, Yi-Jun;Tong, Jie-Wen;Gong, Yu-Shun*;Huang, Jian-An*;...

通讯作者：

Gong, Yu-Shun;Huang, Jian-An;Liu, Zhong-Hua

作者机构：

[Gong, Yu-Shun; Huang, Jian-An; Liu, Zhong-Hua; Xiong, Li-Gui; Chen, Yi-Jun; Tong, Jie-Wen] Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Liu, Zhong-Hua] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha 410128, Hunan, Peoples R China.

[Huang, Jian-An; Liu, Zhong-Hua; Xiong, Li-Gui] Hunan Agr Univ, Collaborat Innovat Ctr Utilisat Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

[Gong, YS; Huang, JA; Liu, Zhong-Hua] 11th North Bldg,Nongda Rd 1, Changsha, Hunan, Peoples R China.

通讯机构：

[Gong, YS; Huang, JA; Liu, ZH] 1

11th North Bldg,Nongda Rd 1, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Epigallocatechin-3-gallate;Healthy lifespan;Mitohormesis;Early-to-mid adulthood;AMPK;C. elegans

期刊：

Redox Biology

ISSN：

2213-2317

年：

2018

卷：

页码：

305-315

DOI：

10.1016/j.redox.2017.09.019

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31270733]; National Tea Industry Technical System Project of China [CARS-23-11B]; Synergistic and Innovative Research Projects for Utilization of Botanical Functional Ingredients [HNCR-2014003]; NIH Office of Research Infrastructure ProgramsUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P40 OD010440]

机构署名：

本校为第一机构

院系归属：

园艺园林学院

摘要：

The green tea polyphenol epigallocatechin-3-gallate (EGCG) is widely consumed as a dietary supplement. Its potential properties include slowing aging and extending lifespan, although how exactly this is achieved remains unclear. Here, we report that EGCG promoted healthy lifespan in Caenorhabditis elegans when administered throughout or only at early-to-mid adulthood. Specifically, EGCG extended lifespan in an inverted U-shaped dose-response manner. The life-extending mechanism was stimulated by EGCG-induced production of reactive oxygen species (ROS). Additionally, EGCG triggered mitochondria...

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Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

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