Epigallocatechin-3-gallate mitigates postovulatory oocyte aging by reducing oxidative stress and promoting embryonic development

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成果类型：

期刊论文

作者：

Gong, Ling;Fan, Ruo-Nan;Peng, Jia;Ni, Xin-Yi;Liu, Yu-Qing;...

通讯作者：

Wang, SL;Wang, HL

作者机构：

[Gong, Ling; Fan, Ruo-Nan; Wang, Shui-Lian] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Gong, Ling; Liu, Yu-Qing; Peng, Jia; Wang, Hai-Long; Fan, Ruo-Nan; Ni, Xin-Yi; Zhang, Dan-Ni; Yan, Xiang-Zhu] Xiamen Univ, Sch Med, Dept Basic Med, Xiamen, Fujian, Peoples R China.

[Fan, Ruo-Nan] Chongqing Hlth Ctr Women & Children, Res & External Affairs Sect, Chongqing, Peoples R China.

[Peng, Jia; Yan, Xiang-Zhu] Hunan Univ Sci & Technol, Coll Life Sci, Xiangtan, Hunan, Peoples R China.

通讯机构：

[Wang, SL ] H

[Wang, HL ] X

Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

Xiamen Univ, Sch Med, Dept Basic Med, Xiamen, Fujian, Peoples R China.

语种：

英文

关键词：

epigallocatechin-3-gallate;fertilization;mice oocyte;oxidative stress;postovulatory oocyte aging

期刊：

REPRODUCTION

ISSN：

1470-1626

年：

2025

卷：

170

期：

DOI：

10.1530/REP-25-0125

基金类别：

National Key Research and Development Program of China [2024YFD1301003]; National Natural Science Foundation of China [32472904, 32172730]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

IN BRIEF: Postovulatory oocyte aging significantly compromises oocyte quality, resulting in fertilization failure, abnormal embryonic development, and unfavorable outcomes in assisted reproductive technology (ART). Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, demonstrates the ability to effectively reduce excessive oxidative stress in oocytes and improve the quality of aged oocytes both in vitro and in vivo, offering promising potential for enhancing the success of ART and efficiency in livestock breeding. ABSTRACT: Oxidative stress-mediated postovulatory agin...

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Epigallocatechin-3-gallate mitigates postovulatory oocyte aging by reducing oxidative stress and promoting embryonic development

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