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Programmable DNA biocomputing circuits for rapid and intelligent screening of SARS-CoV-2 variants

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成果类型:
期刊论文
作者:
Deng, Fang;Pan, Jiafeng;Liu, Zhi;Zeng, Lingwen;Chen, Junhua
通讯作者:
Chen, Junhua(222chenjunhua@163.com)
作者机构:
[Pan, Jiafeng; Deng, Fang; Chen, Junhua] Guangdong Acad Sci, Inst Ecoenvironm & Soil Sci, Natl Reg Joint Engn Res Ctr Soil Pollut Control &, Guangdong Key Lab Integrated Agroenvironm Pollut C, Guangzhou 510650, Peoples R China.
[Liu, Zhi; Pan, Jiafeng; Deng, Fang] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
[Zeng, Lingwen] Guangdong Langyuan Biotechnol Co LTD, Foshan 528313, Peoples R China.
[Zeng, Lingwen] Foshan Univ, Sch Food Sci & Engn, Foshan 528231, Peoples R China.
通讯机构:
[Chen, Junhua] N
National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou, 510650, China. Electronic address:
语种:
英文
关键词:
Logic gate;Biocomputing circuit;Molecular switch;Intelligent screening;COVID-19;SARS-CoV-2 variant
期刊:
Biosensors and Bioelectronics
ISSN:
0956-5663
年:
2023
卷:
223
页码:
115025
基金类别:
Guangdong Basic and Applied Basic Research Foundation; Foshan Science and Technology Innovation Team Project; Wuhan Science and Technology Plan Project; Key Research and Development Projects of Hubei Province; [2021A1515012192]; [2019B1515210019]; [2018IT100343]; [2020030603012347]; [2020BBA053]
机构署名:
本校为其他机构
院系归属:
生物科学技术学院
摘要:
The frequent emergence of SARS-CoV-2 variants increased viral transmissibility and reduced protection afforded by vaccines. The rapid, multichannel, and intelligent screening of variants is critical to minimizing community transmissions. DNA molecular logic gates have attracted wide attention in recent years due to the powerful information processing capabilities and molecular data biocomputing functions. In this work, some molecular switches (MSs) were connected with each other to implement arbitrary binary functions by emulating the threshold switching of MOS transistors and the decision tre...

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