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Viola yedoensis Makino alleviates lipopolysaccharide-induced intestinal oxidative stress and inflammatory response by regulating the gut microbiota and NF-κB-NLRP3/ Nrf2-MAPK signaling pathway in broiler

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成果类型:
期刊论文
作者:
Zhao, Haoqiang;Huang, You;Yang, Wenjiang;Huang, Chunlin;Ou, Zhaoping;...
通讯作者:
Yi, Jine;Kong, L
作者机构:
[Zhao, Haoqiang; Ou, Zhaoping; Wu, Jiao; Kong, Li; Yi, Jine; He, Jiayu; Yang, Yu; Yang, Wenjiang; Huang, You; Yi, JN; Huang, Chunlin; Yang, Mingqi; Yao, Huan] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.
通讯机构:
[Yi, JN; Kong, L ] H
Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.
语种:
英文
关键词:
Broiler;Gut microbiota;Inflammation;Oxidative stress;Viola yedoensis Makino
期刊:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
年:
2024
卷:
282
页码:
116692
基金类别:
National Natural Science Founda- tion of China [32273084]; Innovation Foundation for Postgraduate of Hunan Province, China [CX20220670]; Innovation Foundation for Postgraduate of Hunan Agricultural University, China [2022XC010]
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
Viola yedoensis Makino (Vy) is a well-known traditional Chinese medicine widely used to treat inflammatory diseases. However, the regulatory effects of dietary Vy supplementation on lipopolysaccharide (LPS)-induced intestinal damage in broilers and the underlying molecular mechanisms remain unclear. In this study, broilers were intraperitoneally injected with 1 mg/kg LPS on days 17, 19 and 21 to induce intestinal damage. Vy supplementation at 0.5, 1.5 and 4.5 % in the diet was administered separately for 21 days to investigate the potential p...

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