Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway

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成果类型：

期刊论文

作者：

Cao, Zhe;Wu, Ping;Su, Min;Ling, Hongyan;Khoshaba, Ramina;...

通讯作者：

Cao, Deliang;Zhang, Xuewen;Jin, Junfei

作者机构：

[Cao, Zhe; Liao, Qianjin; Su, Min; Cao, Deliang] Cent S Univ, Xiangya Sch Med, Hunan Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

[Cao, Zhe; Liao, Qianjin; Su, Min; Cao, Deliang] Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

[Cao, Zhe; Chen, Jinjun; Zhang, Xuewen; Gao, Han; Zhao, Yan] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Huang, Chenfei; Wu, Ping; Ling, Hongyan; Cao, Deliang; Khoshaba, Ramina] Southern Illinois Univ, Dept Med Microbiol Immunol & Cell Biol, Sch Med, 913 N Rutledge St, Springfield, IL 62794 USA.

[Wu, Ping] Xiangtan Univ, Sch Chem Engn, Dept Pharmaceut Engn, Xiangtan 411105, Peoples R China.

通讯机构：

[Cao, Deliang] C

[Zhang, Xuewen] H

[Cao, Deliang] S

[Jin, Junfei] G

Cent S Univ, Xiangya Sch Med, Hunan Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

complementary DNA;DNA;long untranslated RNA;long untranslated RNA uasr1;mammalian target of rapamycin;netrin receptor;protein kinase B;rapamycin;short hairpin RNA;unc 5 netrin receptor b;unclassified drug;Akt/mTOR signaling;Article;breast cancer;cell counting;cell migration;cell proliferation;colony formation;comparative study;controlled study;DNA sequence;ectopic expression;human;human cell;intron;MCF-7 cell line;MDA-MB-231 cell line;RNA transcription;sequence analysis;upregulation;wound healing assay

期刊：

JOURNAL OF CANCER

ISSN：

1837-9664

年：

2019

卷：

期：

页码：

2025-2034

DOI：

10.7150/jca.29457

基金类别：

This work was supported in part by National Natural Science Foundation of China (81772842 and 81802947).

机构署名：

本校为通讯机构

院系归属：

生物科学技术学院

摘要：

Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides that function as regulatory factors in many human diseases, including cancer. However, majority of lncRNAs remain to be characterized. In this study, we characterized a novel lncRNA transcript, named UNC5B antisense RNA1 (UASR1). UASR1 is 647bp in length consisting of two exons. This lncRNA is an antisense of intron 1 of unc-5 netrin receptor B (UNC5B) gene. In breast cancer tissues, UASR1 was upregulated. Ectopic expression of UASR1 promoted proliferation and clonog...

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Long non-coding RNA UASR1 promotes proliferation and migration of breast cancer cells through the AKT/mTOR pathway

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