The role of uterus mitochondrial function in high-fat diet-related adverse pregnancy outcomes and protection by resveratrol

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成果类型：

期刊论文

作者：

Yang, Xizi;Hu, Ruizhi;Yao, Liping;Zhang, Wentao;Shi, Mingkun;...

通讯作者：

He, Jianhua;Wu, SS

作者机构：

[He, Xi; Yao, Liping; Zhang, Qianjin; Wang, Ying; Zhang, Wentao; Yang, Xizi; He, Jianhua; Wu, Shusong; Hu, Ruizhi; He, JH; Shi, Mingkun; Gong, Jiatai; Fan, Zhiyong; Yan, Jiahao; Li, Yanli] Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Collaborat Innovat Ctr Utilizat Bot Funct In, Changsha 410128, Peoples R China.

[Yuan, Xupeng] Coll Anim Sci & Technol, Hunan Biol & Electromech Polytech, Changsha 410127, Peoples R China.

[Hou, De-Xing; He, Ziyu] Kagoshima Univ, Fac Agr, Dept Food Sci & Biotechnol, Kagoshima 8900065, Japan.

[Chen, Liang; Zhang, Hongfu] Inst Anim Sci, Chinese Acad Agr Sci, State Key Lab Anim Nutr, Beijing 100081, Peoples R China.

通讯机构：

[Wu, SS ; He, JH] H

Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Collaborat Innovat Ctr Utilizat Bot Funct In, Changsha 410128, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2024

DOI：

10.1039/d4fo00671b

基金类别：

National Natural Science Foundation of China [32102578, U22A20515]; National Natural Science Foundation of China [2023YFD1302300, 2023YFD1301200]; National Key R&D Program of China [22C1053]; Scientific Research Fund of Hunan Provincial Education Department

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

This study elucidates the mechanism of obesity-related adverse pregnancy outcomes and further investigates the effect of resveratrol on reproductive performance in a short- or long-term HFD-induced obese mouse model. Results show that maternal weight had a significant positive correlation with litter mortality in mice. A long-term HFD increased body weight and litter mortality with decreased expression of uterine cytochrome oxidase 4 (COX4), which was recovered by resveratrol in mice. Moreover, HFD decreased the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha...

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The role of uterus mitochondrial function in high-fat diet-related adverse pregnancy outcomes and protection by resveratrol

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