In this paper, two-grid immersed finite element (IFE) algorithms are proposed and analyzed for semi-linear interface problems with discontinuous diffusion coefficients in two dimension. Because of the advantages of finite element (FE) formulation and the simple structure of Cartesian grids, the IFE discretization is used in this paper. Two-grid schemes are formulated to linearize the FE equations. It is theoretically and numerically illustrated that the coarse space can be selected as coarse as H = O(h1/4) (or H = O(h1/8)), and the asymptotical...