Hepatoprotective effect of the ethanol extract of Illicium henryi against acute liver injury in mice induced by lipopolysaccharide

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成果类型：

期刊论文

作者：

Islam, Md Sodrul;Yu, Hui;Miao, Lingyan;Liu, Zhaoying;He, Yanfei;...

通讯作者：

Sun, Hongxiang

作者机构：

[Miao, Lingyan; Sun, Hongxiang; Islam, Md Sodrul; He, Yanfei] Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China.

[Islam, Md Sodrul] Bangabandhu Sheikh Mujibur Rahman Agr Univ, Dept Physiol, Gazipur 1706, Bangladesh.

[Islam, Md Sodrul] Bangabandhu Sheikh Mujibur Rahman Agr Univ, Dept Pharmacol, Gazipur 1706, Bangladesh.

[Yu, Hui; Liu, Zhaoying] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Sun, Hongxiang] Z

Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China.

语种：

英文

关键词：

Illicium henryi;NF-kappaB;Nrf2;TLR4;acute liver injury;lipopolysaccharide

期刊：

Antioxidants

ISSN：

2076-3921

年：

2019

卷：

期：

DOI：

10.3390/antiox8100446

基金类别：

Funding: This research was funded by the National Key R&D Program of China under Grant (no. 2017YFD0501505) and the Dabeinong Funds for Discipline Development and Talent Training in Zhejiang University.

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

The root bark of Illicium henryi has been used in traditional Chinese medicine to treat lumbar muscle strain and rheumatic pain. Its ethanol extract (EEIH) has been previously reported to attenuate lipopolysaccharide (LPS)-induced acute kidney injury in mice. The present study aimed to evaluate the in vitro antioxidant activities and in vivo protective effects of EEIH against LPS-induced acute liver injury (ALI) in mice as well as explore its molecular mechanisms. The mice were injected intraperitoneally (i.p.) with EEIH at the doses of 1.25, 2...

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Hepatoprotective effect of the ethanol extract of Illicium henryi against acute liver injury in mice induced by lipopolysaccharide

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