Mitochondrial Calcium Uniporter Regulator 1 (MCUR1) Relieves Mitochondrial Damage Induced by Lipopolysaccharide by Mediating Mitochondrial Ca2+Homeostasis in Bovine Mammary Epithelial Cells

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成果类型：

期刊论文

作者：

Sun, Xudong;Gao, Shuang;Luo, Shengbin;Chang, Renxu;Jia, Hongdou;...

通讯作者：

Xu, C

作者机构：

[Xu, C; Sun, Xudong; Loor, Juan J.; Chang, Renxu; Luo, Shengbin; Gao, Shuang; Jia, Hongdou; Jiang, Qianming; Xu, Chuang; Xu, Qiushi] Heilongjiang Bayi Agr Univ, Minist Agr & Rural Affairs, Coll Anim Sci & Vet Med,Key Lab Bovine Dis Control, Heilongjiang Prov Key Lab Prevent & Control Bovine, Daqing 163319, Peoples R China.

[Loor, Juan J.; Chang, Renxu] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Loor, Juan J.] Univ Illinois, Dept Anim Sci, Div Nutr Sci, Mammalian NutriPhysioGen, Urbana, IL 61801 USA.

[Xu, C; Xu, Chuang] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China.

通讯机构：

[Xu, C ] H

Heilongjiang Bayi Agr Univ, Minist Agr & Rural Affairs, Coll Anim Sci & Vet Med,Key Lab Bovine Dis Control, Heilongjiang Prov Key Lab Prevent & Control Bovine, Daqing 163319, Peoples R China.

China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China.

语种：

英文

关键词：

mitochondrial calcium homeostasis;MCUR1;bovine mammary epithelial cells;lipopolysaccharide

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2023

卷：

期：

页码：

7278-7288

DOI：

10.1021/acs.jafc.2c07494

基金类别：

National Natural Science Foundation of China (Beijing, China) [32002348, 32125038]; Postdoctoral Scientific Research Devel-opment Fund of Heilongjiang (Heilongjiang, China) [LBH-Q21038]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

The metabolic stress triggered by negative energy balance after calving induces mitochondrial damage of bovine mammary epithelial cells. Mitochondrial calcium uniporter regulator 1 (MCUR1) is a key protein-coding gene that mediates mitochondrial calcium ion (Ca2+) uptake and plays an important role in mediating homeostasis of mitochondria. The aim of the present study was to elucidate the effects of MCUR1-mediated Ca2+ homeostasis on mitochondria of bovine mammary epithelial cells in response to an inflammatory challenge with lipopolysaccharide (LPS). Exogenous LPS resulted in upregulation of ...

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Mitochondrial Calcium Uniporter Regulator 1 (MCUR1) Relieves Mitochondrial Damage Induced by Lipopolysaccharide by Mediating Mitochondrial Ca2+Homeostasis in Bovine Mammary Epithelial Cells

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