Oryzanol alleviates high fat and cholesterol diet-induced hypercholesterolemia associated with the modulation of the gut microbiota in hamsters

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成果类型：

期刊论文

作者：

Yan, Sisi;Chen, Jihong;Zhu, Lingfeng;Guo, Tianyi;Qin, Dandan;...

通讯作者：

Luo, Feijun;Lin, QL

作者机构：

[Chen, Jihong; Luo, Feijun; Lin, Qinlu; Yan, Sisi; Zhu, Lingfeng; Luo, FJ; Guo, Tianyi; Qin, Dandan; Han, Shuai; Hu, Zuomin] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod,Hunan Key L, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Changsha 410004, Hunan, Peoples R China.

[Wang, Ji; Wen, Lixin; Yan, Sisi] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

[Matias, Froilan Bernard] Cent Luzon State Univ, Coll Vet Sci & Med, Dept Anim Management, 3120 Sci City Munoz, Nueva Ecija, Philippines.

通讯机构：

[Lin, QL ; Luo, FJ] C

Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod,Hunan Key L, Hunan Key Lab Grain Oil Deep Proc & Qual Control, Changsha 410004, Hunan, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2022

卷：

期：

页码：

4486-4501

DOI：

10.1039/d1fo03464b

基金类别：

The project was financially supported by the Program for Science & Technology Innovation Platform of Hunan Province (2019TP1029), the Natural Science Foundation of Hunan Province, China (Grant No. 2019JJ50984), the Graduate Innovative Research Project of Hunan province and Central South University of Forestry and Technology (No. CX20200699, CX20201018, and CX2018B457) and the Innovation Fund for Postgraduates of Hunan Province (20183010).

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本校为其他机构

院系归属：

动物医学院

摘要：

A high fat and cholesterol diet (HFCD) can modulate the gut microbiota, which is closely related with hypercholesterolemia. This study aimed to explore the anti-hypercholesterolemia effect of oryzanol, and investigate whether the function of oryzanol is associated with the gut microbiota and related metabolites. 16S rRNA and ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry were applied for the gut microbiota and untargeted metabolomics, respectively. The results showed that HFCD significantly upregulated b...

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Oryzanol alleviates high fat and cholesterol diet-induced hypercholesterolemia associated with the modulation of the gut microbiota in hamsters

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