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Regulatory Effects and Mechanisms of L-Theanine on Neurotransmitters via Liver–Brain Axis Under a High Protein Diet

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成果类型:
期刊论文
作者:
Xu, Wei;Song, Yuxin;Xiao, Wenjun*;Gong, Zhihua
通讯作者:
Xiao, Wenjun;Gong, ZH
作者机构:
[Song, Yuxin; Gong, Zhihua; Gong, ZH; Xiao, Wenjun; Xiao, WJ; Xu, Wei] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.
[Song, Yuxin; Gong, Zhihua; Gong, ZH; Xiao, Wenjun; Xiao, WJ; Xu, Wei] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Hunan, Peoples R China.
[Song, Yuxin; Gong, Zhihua; Gong, ZH; Xiao, Wenjun; Xiao, WJ; Xu, Wei] Coinnovat Ctr Educ Minist Utilizat Bot Funct Ingre, Changsha, Peoples R China.
通讯机构:
[Gong, ZH ; Xiao, WJ] H
Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.
Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Hunan, Peoples R China.
Coinnovat Ctr Educ Minist Utilizat Bot Funct Ingre, Changsha, Peoples R China.
语种:
英文
关键词:
adenylate cyclase;alanine aminotransferase;ammonia;aspartate aminotransferase;brain derived neurotrophic factor;C reactive protein;catalase;cyclic AMP dependent protein kinase;dopamine;guanine nucleotide binding protein alpha subunit;malonaldehyde;proteome;superoxide dismutase;theanine;adverse event;animal behavior;animal cell;animal experiment;animal tissue;Article;body weight;brain region;cognition;controlled study;down regulation;drug mechanism;enzyme blood level;feeding;hepatitis;hippocampal CA1 region;liver brain axis;liver structure;male;nervous system function;neuroprotection;nonhuman;protein blood level;protein diet;protein expression;proteomics;quantitative analysis;rat;signal transduction;Sprague Dawley rat;Western blotting
期刊:
Molecular Neurobiology
ISSN:
0893-7648
年:
2024
卷:
61
期:
2
页码:
783-798
基金类别:
This work was supported by the Natural Science Foundation of Hunan Province, China(2020JJ4036), National Key Research and Development Program of China (2017YFD0400803), and the key R&D program of Hunan Province (2021NK2016).
机构署名:
本校为第一且通讯机构
院系归属:
园艺园林学院
摘要:
Excessive protein intake causes liver and brain damage and neurotransmitter disorders, thereby inducing cognitive dysfunction. L-theanine can regulate the neurotransmitter content and show great potential in liver and brain protection. However, it remains unclear whether l-theanine effectively regulates neurotransmitter content under high-protein diet. A 40-day feeding experiment was performed in Sprague Dawley rats to investigate the regulatory effects and mechanisms of l-theanine on neurotransmitters via liver–brain axis in high-protein diet...

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