The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion

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成果类型：

期刊论文

作者：

Zhou, Z.;Shen, T.;Zhang, B. -H.;Lv, X. -Y.;Lin, H. -Y.;...

通讯作者：

Xue, L. -Q.

作者机构：

[Xue, L. -Q.; Zhou, Z.] Hunan Agr Univ, Coll Vet & Anim Sci, Changsha 410128, Hunan, Peoples R China.

[Zhang, B. -H.; Lv, X. -Y.; Lin, H. -Y.; Zhu, C.; Shen, T.; Wang, H.; Zhou, Z.] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China.

[Zhang, B. -H.; Lv, X. -Y.; Zhou, Z.] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China.

[Shen, T.] Beijing Normal Univ, Dept Life Sci, Beijing 100875, Peoples R China.

通讯机构：

[Xue, L. -Q.] H

Hunan Agr Univ, Coll Vet & Anim Sci, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Furin;Invasion;Migration;Trophoblast;HTR8/SVneo cells

期刊：

Placenta

ISSN：

0143-4004

年：

2009

卷：

期：

页码：

929-938

DOI：

10.1016/j.placenta.2009.09.003

基金类别：

Ministry of Science and Technology of the People's Republic of China [2006CB504006, 2006CB944008]; CAS Knowledge Innovation Program [KSCX2-YW-R-080]; National Natural Science Foundation of China [30811120431, 30670262]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Furin, a proprotein convertase (PC), is ubiquitously expressed and implicated in many physiological and pathological processes. This study is aimed to identify the role of furin in human trophoblast invasion and migration. Furin was found to be highly expressed in placental villi of both rhesus monkeys and human beings during early pregnancy. Specifically, furin was found in trophoblast column and trophoblast shell, regions where highly invasive cytotrophoblast cells invade the maternal decidua during human placentation. To determine whether fu...

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The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion

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