Upregulation of microRNA-32 is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Yang, Huiqiong;Li, Yusheng;Zhong, Xiaoming;Luo, Pei;Luo, Ping;...

通讯作者：

Ma, Yushui;Cong, Xianling

作者机构：

[Yang, Huiqiong; Xie, Ruting; Fu, Da; Ma, Yushui] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Nucl Med & Pathol, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.

[Yang, Huiqiong; Luo, Pei; Li, Wenping] Hunan Agr Univ, Coll Vet Med, Fac Vet, Changsha 410128, Hunan, Peoples R China.

[Li, Yusheng] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.

[Zhong, Xiaoming] Jiangxi Prov Tumor Hosp, Dept Radiol, Nanchang 330029, Jiangxi, Peoples R China.

[Luo, Ping] Nanchang Third Hosp, Dept Breast Canc, Nanchang 330002, Jiangxi, Peoples R China.

通讯机构：

[Ma, Yushui] T

[Cong, Xianling] J

Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Nucl Med & Pathol, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.

Jilin Univ, China Japan Union Hosp, Tissue Bank, 126 Xiantai Blvd, Changchun 130033, Jilin, Peoples R China.

语种：

英文

关键词：

messenger RNA;microRNA;microRNA 32;unclassified drug;adult;aged;Article;cancer prognosis;carcinogenesis;cluster analysis;controlled study;disease free survival;female;gene expression;human;human tissue;liver biopsy;liver cell carcinoma;major clinical study;male;overall survival;reverse transcription polymerase chain reaction;RNA extraction;tumor differentiation;tumor volume;upregulation

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2018

卷：

期：

页码：

4097-4104

DOI：

10.3892/ol.2018.7879

基金类别：

This study was supported partly by grants from the National Natural Science Foundation of China (grant nos. 81201535, 81302065, 81472202, 81772932, 81472209 and 81702243), Jilin Provincial Science and Technology Department (grant no. 20140414061GH), Shanghai Natural Science Foundation (grant nos. 12ZR1436000 and 16ZR1428900) and Shanghai Municipal Commission of Health and Family Planning (grant nos. 201440398 and 201540228). The funding agencies had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

MicroRNA-32 (miR-32) is associated with tumor progression and poor prognosis in certain malignant tumors. However, the function and clinical relevance of miR-32 in human hepatocellular carcinoma (HCC) has not yet been elucidated. The present study aimed to investigate the expression and prognostic value of miR-32 from liver samples in patients with HCC. The expression of miR-32 was analyzed in HCC and healthy tissues using Gene Expression Omnibus datasets. Reverse transcription-quantitative polymerase chain reaction was used to analyze the leve...

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Upregulation of microRNA-32 is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma

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