Glutathione safeguards TET‐dependent DNA demethylation and is critical for the acquisition of totipotency and pluripotency during preimplantation development

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Juan;Chu, Meiqiang;Zhang, Jingyu;He, Jiale;Yang, Qianying;...

通讯作者：

Ren, LK;An, L

作者机构：

[Zhao, Wei; Ouyang, Si; Gao, Shuai; Yang, Qianying; Zhang, Jingyu; Tian, Jianhui; Liu, Juan; Chen, Lei; Zhang, Shuai; An, Lei; Wang, Zhaochen; Ren, Likun; He, Jiale; Tao, Li; Yao, Fusheng; Chu, Meiqiang] China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Minist Agr &, State Key Lab Anim Biotech Breeding,Natl Engn Lab, Beijing, Peoples R China.

[Liu, Juan] Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha, Peoples R China.

[Chu, Meiqiang] Linyi Univ, Coll Agr & Forestry Sci, Linyi, Shandong, Peoples R China.

[Ren, Likun] Beijing Inst Genom, Chinese Acad Sci, Key Lab Genom & Precis Med, Beijing, Peoples R China.

[Ren, Likun] China Natl Ctr Bioinformat, Beijing, Peoples R China.

通讯机构：

[Ren, LK ; An, L ] C

Chinese Acad Sci, Beijing Inst Genom, 1 Beichen West Rd, Beijing 100101, Peoples R China.

China Agr Univ, Coll Anim Sci & Technol, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China.

语种：

英文

关键词：

DNA demethylation;glutathione;pluripotency;preimplantation embryos;TET

期刊：

FASEB JOURNAL

ISSN：

0892-6638

年：

2024

卷：

期：

页码：

e23453-

DOI：

10.1096/fj.202301220R

基金类别：

National Key Research and Development Program of China [2021YFD1200402, 2021YFD1300901]; National Key RD Program [31900603]; National Natural Science Foundation of China [NK20221201]; National Agriculture Key Science & Technology Project [2022TC019]; Chinese Universities Scientific Fund [BAIC05-2024]; Beijing Innovation Consortium of Livestock Research System

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

During early development, both genome-wide epigenetic reprogramming and metabolic remodeling are hallmark changes of normal embryogenesis. However, little is known about their relationship and developmental functions during the preimplantation window, which is essential for the acquisition of totipotency and pluripotency. Herein, we reported that glutathione (GSH), a ubiquitous intracellular protective antioxidant that maintains mitochondrial function and redox homeostasis, plays a critical role in safeguarding postfertilization DNA demethylation and is essential for establishing developmental...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Glutathione safeguards TET‐dependent DNA demethylation and is critical for the acquisition of totipotency and pluripotency during preimplantation development

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问