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Dietary Methionine Restriction Improves Gut Health and Alters the Plasma Metabolomic Profile in Rats by Modulating the Composition of the Gut Microbiota

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成果类型:
期刊论文
作者:
Bi-E Tan;Yulong Yin;Minglong Xia;Qian Xie;Mei Yang;...
通讯作者:
Bi-E Tan<&wdkj&>Yulong Yin
作者机构:
Key Laboratory of Hunan Province for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
Yuelushan Laboratory, Changsha 410128, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China
通讯机构:
[Bi-E Tan] K
[Yulong Yin] A
Authors to whom correspondence should be addressed.<&wdkj&>Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China<&wdkj&>Yuelushan Laboratory, Changsha 410128, China<&wdkj&>Key Laboratory of Hunan Province for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Yuelushan Laboratory, Changsha 410128, China
语种:
英文
关键词:
methionine restriction;intestinal barrier;ZO-1;SCFAs;BAs
期刊:
International Journal of Molecular Sciences
ISSN:
1422-0067
年:
2024
卷:
25
期:
7
页码:
3657-
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
摘要:
Dietary methionine restriction (MetR) offers an integrated set of beneficial health effects, including delaying aging, extending health span, preventing fat accumulation, and reducing oxidative stress. This study aimed to investigate whether MetR exerts entero-protective effects by modulating intestinal flora, and the effect of MetR on plasma metabolites in rats. Rats were fed diets containing 0.86% methionine (CON group) and 0.17% methionine (MetR group) for 6 weeks. Several indicators of inflammation, gut microbiota, plasma metabolites, and intestinal barrier function were measured. 16S rRNA...

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