Development and Recovery of Liver Injury in Piglets by Incremental Injection of LPS

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成果类型：

期刊论文

作者：

Duan, Geyan;Huang, Pan;Zheng, Changbing;Zheng, Jie;Yu, Jiayi;...

通讯作者：

Duan, YH

作者机构：

[Huang, Pan; Duan, Geyan; Zheng, Jie; Yu, Jiayi; Duan, Yehui; Li, Fengna; Guo, Qiuping; Yin, Yulong] Chinese Acad Sci, CAS Key Lab Agroecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Inst Subtrop Agr,Natl Engn Lab Pollut Control & Wa, Changsha 410125, Peoples R China.

[Duan, Geyan; Zheng, Jie; Yu, Jiayi; Duan, Yehui; Li, Fengna; Guo, Qiuping; Yin, Yulong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Zhang, Peiwen; Wan, Mengliao; Zheng, Changbing; Yin, Yulong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.

通讯机构：

[Duan, YH ] C

Chinese Acad Sci, CAS Key Lab Agroecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Inst Subtrop Agr,Natl Engn Lab Pollut Control & Wa, Changsha 410125, Peoples R China.

Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

语种：

英文

关键词：

weaned piglets;liver injury and restoration;lipopolysaccharide

期刊：

Antioxidants

ISSN：

2076-3921

年：

2023

卷：

期：

页码：

1143-

DOI：

10.3390/antiox12061143

基金类别：

This study was jointly supported by the National Natural Science Foundation of China (U19A2037), the Changsha Natural Science Funds for Distinguished Young Scholar (kq2009020), the Science and Technology Innovation Program of Hunan Province (2022RC1159), the Natural Science Foundation of Hunan Province (2021JJ20044), the Natural Science Foundation of Guangxi Province (2020JJA130102), the National Key Research and Development Programs of China (2022YFD1300503), and the China Agriculture Research System of MOF and MARA (CARS-35).

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

This study aimed to explore the effects of the incremental injection of lipopolysaccharide (LPS) on liver histopathology, inflammation, oxidative status, and mitochondrial function in piglets. Forty healthy Duroc x Landrace x Yorkshire castrated boars (21 +/- 2 days old, weight 6.84 +/- 0.11 kg) were randomly assigned to five groups (n = 8) and then slaughtered on days 0 (group 0, without LPS injection), 1 (group 1), 5 (group 5), 9 (group 9), and 15 (group 15) of LPS injection, respectively. The results showed that, compared to the piglets without LPS injection, LPS injection caused liver inju...

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Development and Recovery of Liver Injury in Piglets by Incremental Injection of LPS

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