Betulinic acid alleviates zearalenone-induced uterine injury in mice

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成果类型：

期刊论文

作者：

Yang, Chenglin;Chen, Yunqin;Yang, Mengran;Li, Jiayan;Wu, You;...

通讯作者：

Wu, Jing(wujing@hunau.edu.cn)

作者机构：

[Chen, Yunqin; Li, Jiayan; Wang, Siqi; Yi, Jine; Ning, Can; Fan, Hui; Xiao, Wenguang; Wu, You; Yuan, Zhihang; Wu, Jing; Yang, Mengran; Kong, Xiangyi; Yang, Chenglin] Hunan Agr Univ, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

通讯机构：

[Wu, J.] H

Hunan Engineering Research Center of Livestock and Poultry Health Care, China

语种：

英文

关键词：

Zearalenone;Betulinic acid;Oxidative stress;Estrogen receptor;Cell proliferation and apoptosis;MAPK signaling pathway

期刊：

Environmental Pollution

ISSN：

0269-7491

年：

2023

卷：

316

期：

Pt 1

页码：

120435

DOI：

10.1016/j.envpol.2022.120435

基金类别：

This work was supported by the Natural Science Foundation of Hunan province ( 2021JJ30343 and 2020JJ4368 ); The Key Research and Development Program of Hunan Province ( 2020NK2032 ); Innovation Research and Development Project of Hunan Development and Reform Commission (Grant No. 37 ).

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Zearalenone (ZEA) is a mycotoxin with estrogen-like biological activity, which widely present in feed and raw materials, with strong reproductive system toxicity and a major threat to animal reproduction. Betulinic acid (BA) is a natural plant compound with antioxidant, anti-inflammatory and other pharmacological activities. However, the mechanism of ZEA-induced uterine injury and the protective effect of BA have not been reported. Our results show that ZEA could cause uterine histopathological damage and cellular ultrastructural damage, affect...

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Betulinic acid alleviates zearalenone-induced uterine injury in mice

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