Gossypol is a yellow polyphenolic compound from cotton plant. It has been shown to exert a potential for anti-cancer, anti-inflammatory and anti-fertility effects. Following effects of gossypol acetic acid (GA) in mice were determined in the present study: influence on the total number of lymphocytes, weight ratio and subsets of lymphocytes in the thymus, spleen and mesenteric lymph nodes, and humoral immune response to sheep erythrocytes (SRBC). Gossypol acetic acid was administered orally four times at 24 h intervals at three doses of 5.0, 25.0 and 125.0 mg/kg to SRBC-immunized mice (prior t...
